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Tumor Dormancy and Recurrence

Tumor Dormancy and Recurrence

Tumor Dormancy and Recurrence Ebook

Tumor Dormancy and Recurrence Ebook

 

Abstract

This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions.

 

Table of content

Content: Preface
Contents
Epigenetic Regulation of Cancer Dormancy as a Plasticity Mechanism for Metastasis Initiation
Introduction
Cancer Cell Dormancy within the Dogma of Metastasis
Defining Dormancy States
Microenvironmental Signals Regulate Dormancy
Epigenetic Regulation of Dormancy Transcriptional Programs
Transcriptional Programs in Adult Stem Cells and Dormant Cancer Cells
Transcriptional Programs in Dormant Residual Disease in Patients
Conclusions
References
Biological and Clinical Evidence for Metabolic Dormancy in Solid Tumors Post Therapy
Introduction The Derangement of Metabolic Wiring in Cancer ‘Metabolic’ Dormancy and Related Biological Mechanisms
Regulation of Metabolic Dormancy
Technological, Biological, and Clinical Challenges to Study Metabolic Tumor Dormancy
Premise of Therapeutic Targeting of Metabolic Dormancy
Conclusions
References
Tumor Dormancy, Angiogenesis and Metronomic Chemotherapy
Introduction
The Role of Angiogenesis in Tumor Dormancy
Metronomic Chemotherapy as an Inducer of Angiogenic Tumor Dormancy: A Promising Research Field Metronomic Chemotherapy and the Anti/pro-Angiogenic Growth Factor Equilibrium Metronomic Chemotherapy and the Circulating Endothelial Progenitors
Conclusions
References
Immuno-oncology of Dormant Tumours
Anti-cancer Immunity: An Overview
Dormant Tumour-Immune System Interactions
Immunotherapy for Dormant Tumours
References
Thermodynamics and Cancer Dormancy: A Perspective
Introduction: Entropy and Information
Complexity of Cancer
Molecular Scale
Cellular Scale
Tissue Scale
Metabolic Entropy Increase in Cancer
Organismal Scale
Epidemiological Scale
Conclusions

 

Ebook details:

Title: Tumor Dormancy and Recurrence

Author: Yuzhuo Wang and Francesco Crea

Publisher: Springer International Publishing

Edition: ۱st

Langage: English

Format: eBook High-Quality True PDF with pagination & index

Size: ۲ Mb

Year: ۲۰۱۷

ISBN: 3319592408,  ۹۷۸۳۳۱۹۵۹۲۴۰۴

eISBN: 3319592424, ۹۷۸۳۳۱۹۵۹۲۴۲۸

 

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